Is it possible to enable agent caching for wan peering?

As per title, I recently found out about agent caching and would like to know the following:

Datacenter A - has many services that would watch service B (each service has a sidecar, so not much effect from enabling caching on sidecars)
Datacenter B - has service B

Both datacenters are wan joined, so my question is - is it possible to enable caching on datacenter B, so requests from sidecar get cached response?